defining characteristics
Spine sclerosis with sandwich vertebrae (rugger jersey spine), variable penetrance/ severity
disease development
Mutation in TC1RG1 causes inability of osteoclast to secrete hydrogen ions into the bone matrix, thereby decreasing bone resorption
potential causes
epidemiology
Late childhood/ adolescence onset
risk factors
labimaging
XR? Rugger jersey spine
conventional treatment
complications
Fractures, osteomyelitis, possible nerve compression
