Home Osteopetrosis: Autosomal dominant (Albers-Schonberg) (ARO)

Osteopetrosis: Autosomal dominant (Albers-Schonberg) (ARO)

Spine sclerosis with sandwich vertebrae (rugger jersey spine), variable penetrance/ severity

Mutation in TC1RG1 causes inability of osteoclast to secrete hydrogen ions into the bone matrix, thereby decreasing bone resorption

Late childhood/ adolescence onset

XR? Rugger jersey spine

Fractures, osteomyelitis, possible nerve compression

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