defining characteristics
Gradual appearance of symmetric hyperostosis on periosteal and endosteal surfaces of long bones
disease development
Mutation in TGF-B1, a latency protein that is a normally a chronic sequesterer and inhibitor of TGF-B in bone
potential causes
Unregulated TGF-B causes overstimulation of osteoblasts and excessive bone formation
epidemiology
Variable age, severity, course
risk factors
labimaging
conventional treatment
Glucocorticoids for pain relief
