Types
Defining Characteristics
Gradual appearance of symmetric hyperostosis on periosteal and endosteal surfaces of long bones
Disease Development
Mutation in TGF-B1, a latency protein that is a normally a chronic sequesterer and inhibitor of TGF-B in bone
Potential Causes
Unregulated TGF-B causes overstimulation of osteoblasts and excessive bone formation
Epidemiology
Variable age, severity, course
Conventional Treatment
Glucocorticoids for pain relief