Home Ehlers Danlos Syndrome (EDS): Classical

Ehlers Danlos Syndrome (EDS): Classical


Defining Characteristics

Skin & joint hypermobility (Beighton’s score >5 for joints), atrophic scarring (not well healed), easy bruising, smooth/velvety skin, hypotonia & decreased motor development

Disease Development

Mutation in collagen type V (COL5A1, COL5A2), disrupting structural integrity of connective tissues


1/5000 individuals; classical form is most common

Risk factors

Autosomal dominant


Clinical exam for manifestations Beighton score
baseline echocardiogram for kids <10 y.o. Evaluate clotting factors

Conventional Treatment

Tx manifesting sx
Low-resistance exercise to increase muscle tone
Vit. C & D, Ca supplem Avoid high impact force


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