Types
Defining Characteristics
Very serious bc blistering in middle skin layers
Generalized blisters at birth, periorificial granulation tissue, nail shedding/dystrophy, denuded areas, enamel defects, growth retardation, anemia, epithelial blistering of mucosal membranes (Resp, GI, GU)
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Disease Development
Blistering in the lamina lucida
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Potential Causes
premature stop codon in laminin 5 genes
sometimes defects w/ collagen 17 or B4/a6 integrins
Complications
Can be lethal in early childhood