Mitochondrial myopathy

defining characteristics

Maternal transmission, extra-muscular manifestations (in tissues/organs w/ high met rates)
Furrowed brow, high-arched eyebrows
Progressive External Opthalmoplegia (PEO) Рptosis,
opthalmoparesis
MELAS – stroke <40, encephalopathy, RRF, lactic acidosis MERRF- myoclonus, epilepsy, ataxia, ragged red fibers

disease development

Abnormal amounts of mitochondria

potential causes

epidemiology

risk factors

labimaging

Histology? Ragged red fibers representing abnl excess mitochondria

conventional treatment

complications

prevention

protocols