Home Pemphigus

Pemphigus

Types

Sunburn , Albinism , Vitiligo , Viral Hepatitis , Epidermolysis bullosa (EB) , General , EB Simplex , Junctional , Dystrophic (Recessive-RDEB or Dominant- DDEB) , Epidermolysis bullosa acquisita , Bullous pemphigoid , Mucus membrane pemphigoid , Ocular cicatricial pemphigoid , Pemphigus vulgaris , Pemphigus foliaceus , General , Acute dermatitis (eczema) , Chronic dermatitis , Subacute dermatitis , Atopic Dermatitis (AD) , Stasis Dermatitis (SD) , Lichen Simplex Chronicus (LSC) , Contact Dermatitis - Irritant , Contact Dermatitis - Allergic (ACD) , Seborrheic Dermatitis , Bacterial folliculitis , Hot tub folliculitis , Verruca vulgaris , Verruca plantaris , Condylomata acuminata , Filiform warts , Verruca plana , Sclerosteosis , Van Buchem , Worth type , Acute , Chronic , Hematogenous , Contiguous , Acute bacterial , Chronic septic arthritis , Disseminated gonococcial infection (DGI) , Early (<3m after surgery) , Delayed (3-24m) , Late (>2y) , Classical , Hypermobility , Arthrochalasia , Vascular , Dermatosparaxis , Kyphoscoliosis , Duchenne MD , Becker's MD , Myotonic dystrophy type I , Acute , Chronic , Monomicrobial , Polymicrobial , Giant Melanocytic Nevus , Polyostotic Monostotic , Autosomal recessive infantile malignant (ARO) , Autosomal dominant (Albers-Schonberg) (ARO) , Camurati-Engelmann , Benign , Benign , Benign , McArdle's disease , Carnitine palmitoyltransferase II deficiency , Mitochondrial myopathy , Dermatomyositis , Polymyositis , Inclusion body myopathy , Soft tissue pain disorder , Episodic monoarticular Polyarticular Tophaceous gout , Central core disease , Basal Cell Nevus Syndrome (BCNS) , Xeroderma pigmentosum (XP) , Sun tan , Ichthyosis , Psoriasis , Ectodermal Dysplasia , Keloid , Acne , Tinea versicolor , Molluscum Contagiosum , Varicella Zoster Virus (VZV) (Shingles) , Scabies , Eryisipelas , Gas gangrene (myonecrosis) , Osteoporosis , Pycnodysostosis , Carbonic Anhydrase II deficiency , Fibrodysplasia ossificans progressive (FOP) , Marfan Syndrome , Stickler Syndrome , Achondroplasia , Polymyalgia Rheumatica (PR)

Disease Overview

A Pemphigus is a skin disease in which watery blisters form under the skin.

Defining Characteristics

Inter-epidermal blisters, jagged & flaccid blisters w/ positive Nikolsky sign (easy to deform w/ slight pressure), hyperpigmentation in healing areas, not too much scarring, severe nail disease, oral lesions

Epidemiology

N/A

Risk factors

N/A

Lab/Imaging

Histology? Basal epidermis still attached to BM, and rete ridges still visible but huge white space above represents blister (suprabasal split)
Chicken wire appearance w/ direct immunofluorescence

Conventional Treatment

Immunosuppressants, corticosteroids; new therapies (tyrosine kinase inhibitors to increase resistance to pemphigus IgG)

Complications

side effects of steroids; high fatality w/o tx