A sunburn is when you can start to see reddening, inflammation, and, in severe cases, blistering and peeling of the skin caused by overexposure to the ultraviolet rays of the sun.
clinical variants
N/A
defining characteristics
Inflammation, erythema
pathogenesis
Determined by total UVB energy absorbed (ind of duration)
Inflammation (cytokines, histamine, prostaglandins, serotonin) cause redness; increased adhesion protein expression --> immune cell recruitment
etiologies
Failed or incomplete repair of thymine dimers
--> mutations in p53 (higher risk for non- melanoma skin cancers)
epidemiology
risk factors
labimaging
Histology?
Endothelial swelling, decreased langerhans, neutrophil recruitment, apoptotic keratinocytes (bright pink)
areas of hyperplasia (thickened stratum corneum, epidermis, dermis)
conventional treatment
complications
Major risk factor for non- melanoma and melanoma skin cancers
screeningeducation
N/A
disease development
Determined by total UVB energy absorbed (ind of duration)
Inflammation (cytokines, histamine, prostaglandins, serotonin) cause redness; increased adhesion protein expression –> immune cell recruitment
potential causes
Failed or incomplete repair of thymine dimers
–> mutations in p53 (higher risk for non- melanoma skin cancers)
