Sunburn

A woman applies sunblock at the beach

A sunburn is when you can start to see reddening, inflammation, and, in severe cases, blistering and peeling of the skin caused by overexposure to the ultraviolet rays of the sun.

clinical variants

N/A

defining characteristics

Inflammation, erythema

pathogenesis

Determined by total UVB energy absorbed (ind of duration)
Inflammation (cytokines, histamine, prostaglandins, serotonin) cause redness; increased adhesion protein expression --> immune cell recruitment

etiologies

Failed or incomplete repair of thymine dimers
--> mutations in p53 (higher risk for non- melanoma skin cancers)

epidemiology

risk factors

labimaging

Histology?
Endothelial swelling, decreased langerhans, neutrophil recruitment, apoptotic keratinocytes (bright pink)
areas of hyperplasia (thickened stratum corneum, epidermis, dermis)

conventional treatment

complications

Major risk factor for non- melanoma and melanoma skin cancers

screeningeducation

N/A

disease development

Determined by total UVB energy absorbed (ind of duration)
Inflammation (cytokines, histamine, prostaglandins, serotonin) cause redness; increased adhesion protein expression –> immune cell recruitment

potential causes

Failed or incomplete repair of thymine dimers
–> mutations in p53 (higher risk for non- melanoma skin cancers)

prevention

protocols