defining characteristics
Verrucus (bumpy/rough), hyperkeratotic skin colored papules; usually asymptomatic unless 2ndary infection/inflammation
disease development
Infection of basal layer of skin with HPV (dsDNA virus), resulting in the slow division of cells in the spinous layer; eventually leads to hyperkeratosis and papillomatosis
Transmitted from skin to skin contact, autoinoculation, contaminated surfaces
potential causes
HPV 2, 4
epidemiology
VERY common 20% of kids have at some time
risk factors
Often none HIV
Organ transplantation
labimaging
Histology? Hyperkeratosis of epidermis and granular layer, inward bending of rete ridges, papillomatosis (fingerlike projections of epithelia)
Clinical Bx (rare)
DNA testing to determine type of HPV present
conventional treatment
Spontaneously resolution (SLOW)
Various OTC tx modalities that aren’t all that effective (Salicylic acid, imiquimod, duct tape)
Paring Cryosurgery
Podophyllin (topical chem agent)
complications
Possible some HPV types are cancer-forming
